Impact of vitamin D therapy on decreasing of proteinuria in type 2 diabetic patients

Abstract

© 2017 The Author(s).Background: Vitamin D (Vit D) deficiency is a common disorder in diabetic patients and may be a risk factor for ischemic heart disease and exacerbation of diabetic nephropathy (DN). Objectives: The aim of this study was to evaluate the effect of Vit D3 therapy on proteinuria in type 2 diabetic patients with deficient or insufficient serum Vit D. Patients and Methods: In a double blind clinical trial,60 type 2 diabetic patients with proteinuria greater than 150 mg/day who had Vit D deficiency or insufficiency were randomly enrolled in two equal groups. Pearl of Vit D as 50 000 IU/week and placebo (1 tablet per week) were prescribed in patients of case and control groups respectively for 8 weeks. At the beginning and 2 months later,24 hours urine protein was checked in all patients. Results: There is no difference between serums Vit D level in case and control group at the beginning of the study,however at the end of the study serum Vit D level was significantly higher in the case group. There is no difference in proteinuria between case and control group at the beginning and the end of the study,while a significant difference between the changes of proteinuria before and after the study was seen in two groups (P = 0.028). Conclusions: Vit D deficiency may exacerbate proteinuric and DN,hence correction of Vit D deficiency may decrease proteinuria in diabetic patients with nephropathy.