When the drugs don't work: The potential of glutamatergic antipsychotics in schizophrenia

Abstract

Currently available antipsychotic drugs target dopaminergic neurotransmission. Many patients do not respond fully to these treatments, and there has been considerable effort to investigate alternative targets. Here we summarise the rationale and recent evidence supporting efforts to develop glutamatergic antipsychotic drugs. © The British Journal of Psychiatry 2013.