We investigated the feasibility of including plasma anti-NMDAR antibody screening in the assessment of first-episode psychosis patients in an early intervention programme in the Southern hemisphere. Anti-NMDAR IgG antibodies were assessed by ELISA in 166 patients (64.0% men), 166 matched population-based controls and 76 patients’ siblings (30.3% men). Fisher’s exact test and ANOVA were performed. Positive anti-NMDAR antibody patients were more often observed in bipolar disorder (10.0%) than schizophrenia (2.4%) or psychotic depression (3.1%), although no significant differences were observed. Our results are not conclusive regarding the inclusion of plasma anti-NMDAR IgG antibodies in differential diagnostic protocols for psychosis.
CITATION STYLE
Loureiro, C. M., Corsi-Zuelli, F., Fachim, H. A., Shuhama, R., de Souza Chagas, N. M., Menezes, P. R., … Louzada-Junior, P. (2021). Plasma prevalence of anti-n-methyl-d-aspartate receptor igg antibodies in early stages of psychosis. Ciencia e Saude Coletiva, 26(3), 1085–1094. https://doi.org/10.1590/1413-81232021263.07552019
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