Five new phenolic compounds with antioxidant activities from the medicinal insect Blaps rynchopetera

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Abstract

Five new phenolic compounds rynchopeterines A–E (1–5), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A–E (1–4) exhibited significant antioxidant activities with IC50 values of 7.67–12.3 µg/mL measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Besides, rynchopeterines B (2) and C (3) showed mild cytotoxicity against tumor cell Caco-2 and A549.

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Xiao, H., Yin, T. P., Dong, J. W., Wu, X. M., Luo, Q., Luo, J. R., … Ding, Z. T. (2017). Five new phenolic compounds with antioxidant activities from the medicinal insect Blaps rynchopetera. Molecules, 22(8). https://doi.org/10.3390/molecules22081301

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