Protective effect of folic acid against arsenic induced weight loss during gestation, lactation and postnatal growth in mice

Abstract

Aim : The present study aimed to determine weight loss in sodium arsenate exposed pups during gestation, lactation and postnatal growth. Additionally, the protective role of folic acid was also assessed against impaired growth caused by arsenic during three developmental stages. Methodology : Twenty pregnant albino mice were divided into four groups and received the following treatment in their drinking water from gestational day one (G1): control group, 1 mg l-1 As 1 mg l-1 As + 25 mg kg FA(As + FA) by ip once a week during gestation and lactation and 25 mg kg-1 folic acid (FA) groups. After weaning, the litters were directly exposed to arsenic and folic acid with the same dosage. Results : Exposure to arsenic exhibited a significant (P<0.01) growth impairment in the weight of offspring during lactation (1st -3rd week) and 22-56 ds postnatal (PN) in the As-treated group. The administration of FA through gestation and lactation by dams after 2 months could significantly (P<0.01) prevent As-induced weight loss in the developmental stages. Treatment with FA resulted in significantly decrease (P<0.05) of AS level in liver and brain. Interpretation : These observations indicate that vitamin administration could prevent growth impairments of arsenic exposure.