On the road to combinations of targeted therapies: PPM1H phosphatase as a suppressor of trastuzumab resistance

Abstract

Lee-Hoeflich and colleagues use RNA interference screening to identify the serine/threonine phosphatase PPM1H as an inhibitor of trastuzumab resistance in vitro. This finding extends the molecular portrait of trastuzumab-resistant cells and provides a rationale when searching for potential therapeutic targets among regulators of PPM1H and/or its substrates. © 2011 American Association for Cancer Research.