Oncothermia - Nano-heating paradigm

Abstract

To face the challenges in hyperthermic oncology we have made research on nano-heating the malignant and healthy cells and this review paper shows our results which were presented at the largest OMICS Group Conference in the United States in 2013. We introduced nano-heating technology which means selecting and heating the membrane of the malignant cells purely by the electromagnetic effects without any extra nano-particle applications. The technology (called modulated electrothermia or oncothermia) is impedance controlled capacitive coupling, no plane-wave radiation is dominating as in other capacitive (radiative) solutions. The nano-selection is based on the metabolic, on the adherent and on the organizing deviations of the malignant cells from their healthy hosts. The cell-killing mechanism is connected to the intensive, but very local, nano-range heating. These effects are proven in silico, in vitro and in vivo experiments, as well as in pre-clinical and veterinarian applications. Based on the controllable and safe methodology the treatment is applied in human clinical practice. My objective is to summarize the results which are connected with oncothermia method. © 2014 Szasz O, et al.