Microwave-promoted heck and suzuki coupling reactions of new 3-(5-bromobenzofuranyl)pyrazole in aqueous media

Abstract

Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions of 3-(5-bromobenzofuran-2-yl)-1H-pyrazole with various arylboronic acids and terminal olefins, respectively, were investigated using a benzothiazole-oxime palladium(II) complex, under both thermal and microwave-irradiation conditions, in an open vessel, using aqueous solvent. The benzothiazole-oxime-based Pd(II) complex was found to be an efficient, and highly active pre-catalyst for the cross-coupling reactions, and for the preparation of new C-C cross-coupled compounds of potential biological interest which are difficult to obtain using other synthetic routes.