Dynamic changes in arterial pressure following high cervical transection in the decerebrate rat

Abstract

Objective: Spinal transection has variable effects on arterial pressure, with some investigators demonstrating a precipitous decline and others reporting only a minimal decrease below normal. Recovery of arterial pressure following spinalization occurs with varying time courses–in some cases over days and in others over weeks to months. Given these findings, we sought to systematically test the hypothesis that in the unanesthetized decerebrate rat, arterial pressure would recover to pre-transection values over an acute time course. Design: Experiments were performed on a total of six Sprague–Dawley unanesthetized decerebrate adult male rats. In four rats, we determined dynamic changes in arterial pressure and heart rate in response to C1 transection. Results: Immediately following spinal cord injury, there were significant decreases in systolic blood (SBP) and mean arterial pressure (MAP), but not diastolic blood pressure (DBP). SBP, DBP, and MAP were significantly greater 170 min post-transection compared to immediate and 5 min-post transection values and were not statistically significantly different from pre-transection control. Heart rate decreased significantly following transection, but not immediately following the spinal cord injury. Lung inflation elicited depressor responses in all animals tested (n = 4 animals) and in three animals resulted in bradycardia. Hypercapnia tests effected a decrease in arterial pressure and heart rate (n = 3 animals). Conclusions: We demonstrate that in the unanesthetized decerebrate spinalized animal, arterial pressure is reduced by spinal transection and recovers over an acute time course to pre-transection values.