Antioxidant, anti-inflammatory and anticoagulant activities of sulfate polysaccharide isolate from brown alga Sargassum policystum

Abstract

This study investigated the effect of sulphate polysaccharide isolate obtained from brown algae Sargassum polycistum on their biological activities. The antioxidant activity using FRAP (Ferric Reducing Antioxidant Power) method showed an IC50 value of 91.306 ppm compared to vitamin C as a positive control, with an IC50 value of 4,1667 ppm sulphate polysaccharide isolate showing intense antioxidant activity. In vivo anti-inflammatory activity of sulphate polysaccharide isolate from the brown algae has been done using CFA (Completed Freund's Adjuvant). This study used 25 mice divided into five groups, namely the positive control group, negative control, the sulphate polysaccharide isolate compounds (doses of 10, 50, and 250 mg/kg). The results showed that the sulphate polysaccharide isolate had an anti-inflammatory effect that was not signed with positive controls but it was significantly different from negative controls. In anticoagulant activity, 25 mice were divided into five treatment groups: negative control, positive control, sulphate polysaccharide isolate sample with the dosage of 25, 50 and 100 mg/kg. The results showed that the sulphate polysaccharide isolate dosage of 100 mg/kg has anticoagulant activity. It can be concluded that sulphate polysaccharide isolates isolate has the potency to prevent and treat cardiovascular disease.