Disorders of Gut–Brain Interaction and the Rome V Process

Abstract

Disorders of gut–brain interaction (DGBI) are characterized by gastrointestinal symptoms related to any combination of motility disturbance, visceral hypersensitivity, altered mci function, altered gut microbiota, or altered central nervous system processing. Research on and clinical management of DGBI is based on selective diagnostic criteria, generated through the Rome Foundation. The Rome V process generated a broad overview of the knowledge accumulated since Rome IV was published 10 years ago, with a focus on evidence-based adjustments. It builds on (1) an update of the DGBI definitions based on the latest basic and clinical literature; (2) offering new information on the role of diet, gut microenvironment, gut–brain interactions, pharmacogenomics, biopsychosocial, gender and cross-cultural factors; (3) reducing the use of imprecise or stigmatizing terms; (4) generating updated diagnostic algorithms; (5) incorporating information on the patient illness experience and sociocultural aspects; and (6) updating the therapeutic approaches to DGBI.