A motor neuron protective role of miR-969 mediated by the transcription factor kay

2Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Maintenance of motor neuron structure and function is crucial in development and motor behaviour. However, the genetic regulatory mechanism of motor neuron function remains less well understood. In the present study, we identify a novel neuroprotective role of the microRNA miR-969 in Drosophila motor neurons. miR-969 is highly expressed in motor neurons. Loss of miR-969 results in early-onset and age-progressive locomotion impairment. Flies lacking miR-969 also exhibit shortened lifespan. Moreover, miR-969 is required in motor neurons. We further identify kay as a functionally important target of miR-969. Together, our results indicate that miR-969 can protect motor neuron function by limiting kay activity in Drosophila.

Cite

CITATION STYLE

APA

Zhang, X., Lyu, J., Jin, X., Yang, W., Lou, Z., Xi, Y., … Ge, W. (2020). A motor neuron protective role of miR-969 mediated by the transcription factor kay. RNA Biology, 17(9), 1277–1283. https://doi.org/10.1080/15476286.2020.1757897

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free