The targeting of non‑coding RNAs by curcumin: Facts and hopes for cancer therapy (Review)

Abstract

Curcumin [(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione] is a natural polyphenol that is derived from the turmeric plant (curcuma longa L.). Curcumin is widely used in food coloring, preservatives, and condiments. Curcumin possesses anti‑tumor, anti‑oxidative and anti‑inflammatory efficacy, as well as other pharmacological effects. Emerging evidence indicates that curcumin alters microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in various types of cancers. Both miRNAs and lncRNAs are non-coding RNAs that can epigenetically modulate the expression of multiple genes via post-transcriptional regulation. In the present review, the interactions between curcumin and non-coding RNAs are summarized in numerous types of cancers, including lung, colorectal, prostate, breast, nasopharyngeal, pancreatic, blood, and ovarian cancer, and the vital non-coding RNAs and their downstream targets are described.