Targeting high circulating dipeptidyl peptidase 3 in circulatory failure

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Abstract

Circulating dipeptidyl peptidase 3 is a new biomarker linked to circulatory failure prognosis and pathophysiology and is a potential actionable therapeutic target. In this short review intended for the clinician, a question-and-answer format provides key insights on the nature of this biomarker and the therapeutical potential of its targeted inhibition in critically ill patients.

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Picod, A., Azibani, F., Harjola, V. P., Karakas, M., Kimmoun, A., Levy, B., … Mebazaa, A. (2025). Targeting high circulating dipeptidyl peptidase 3 in circulatory failure. Critical Care, 29(1). https://doi.org/10.1186/s13054-025-05545-x

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