Ultrasound-mediated one-pot synthesis of 7-methyl-substituted pyrido[4,3- d ]pyrimidine scaffolds by a catalyst-free protocol

Abstract

A one-pot and catalyst-free protocol for the construction of 7-methyl-substituted pyrido[4,3-d]pyrimidine derivatives from ethanolic solution of 6-[2-(dimethylamino)prop-1-enyl]-1,3-dimethyluracil, Aaromatic aldehyde, and ammonium acetate is described under both ultrasound and thermal conditions. The ultrasound methodology is clean and the desired products are obtained with good yields in short time.