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Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei

Bioscience, Biotechnology and Biochemistry (2012) 76(6) 1233-1235
DOI: 10.1271/bbb.110994
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Abstract

An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

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Yuki, K., Ikeda, M., Miyamoto, K., Ohno, O., Yamada, K., & Uemura, D. (2012). Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei. Bioscience, Biotechnology and Biochemistry, 76(6), 1233–1235. https://doi.org/10.1271/bbb.110994

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