Shear-driven flow approaches to LC and macromolecular separations

Abstract

Doing away with the pressure- and voltage-drop limitations that prohibit the application of larger mobile-phase velocities might have a fundamental impact on LC and macromolecular separations. David Clicq, Kris Pappaert, Sarah Vankrunkelsven, Nico Vervoort, Gino V. Baron, and Gert Desmet of Vrije Universiteit Brussel (Belgium) describe their work on micro- and nanochannel separation methods that use shear forces as an alternative to conventional flow-driving methods.