P1186Impact of Helicobacter pylori recurrence on long-term clinical outcomes in patients with atrial fibrillation

Abstract

Introduction: Relationship between atrial fibrillation (AF) and inflammation was shown in previous studies. However, there was limited data about the association between the Helicobacter pylori (H.pylori) and AF in the long-term follow up. Purpose: The aim of this study was to evaluate the impact of H.pylori on long-term clinical outcomes in patients with AF. Methods: The Kosin University echocardiography, electrocardiogram (ECG) and H.pylori database were reviewed from 2012 to 2017 to identify patients with AF and H.pylori. Patients were followed for a mean 25.260.6 months and were divided into two groups according to the absence or presence of H.pylori in patients with AF. Results: Among 303 patients with AF, 123 (40.6%) patients had H.pylori. There was no difference of arrhythmic events in both group. However, total any event rates including thromboembolic events, arrhythmic events, re-hospitalizations and mortality were significantly higher in patients with H.pylori compared to those without H.pylori (P<0.001). In subgroup analysis with H.pyroli, hypertension, smoke, H,pylori recurrence after eradication, age, E/E' (the peak mitral flow velocity of the early rapid filling wave/early diastolic mitral annulus velocity), and CHA2DS2 VASc score were significantly associated with neurologic events including stroke, transient ischemic attack in univariate analysis. In multivariate analysis, H,pylori recurrence was independent risk factors for neurologic events (P=0.018) at the long-term follow-up. Conclusion: The H.pyroli recurrence was associated with higher incidence of neurologic events in patients with AF, suggesting more intensive medical therapy with close clinical follow-up will be required.