The role of FOXP3 in disease progression in colorectal cancer patients

Abstract

The transcription factor forkhead box P3 (FOXP3) has been identified as a marker of CD4+CD25+ regulatory T cells and is a key determinant of their immunosuppressive functions. FOXP3 has indeed been shown to limit antitumor immune responses during tumor progression. In addition, by expressing FOXP3, tumor cells may evade effector T-cell responses. © 2013 Landes Bioscience.