Precise detection of direct glomerular input duration by the olfactory bulb

Abstract

Sensory neuron input to the olfactory bulb (OB) was activated precisely for different durations with blue light in mice expressing channelrhodopsin-2 inolfactory sensory neurons. Behaviorally the mice discriminated differencesof10msindurationofdirect glomer-ular activation. In addition, a subset of mitral/tufted cells in the OB of awake mice responded tonically therefore conveying information on stimulus duration. Our study provides evidence that duration of the input to glomeruli not synchronized to sniffing is detected. This potent cue may be used to obtain information on puffs in odor plumes.