Human iPSC-derived neural stem cells displaying radial glia signature exhibit long-term safety in mice

Abstract

Cell products derived from human induced pluripotent stem cells hold promise for regenerative therapies, but the safety of these transplanted cells must be carefully assessed. Here they show that hiPSC-derived neural stem/progenitor cells are able to stably engraft and generate glia cells in transplanted mouse brains with no evidence of tumor formation.