Synthesis of Thiazolidine-2-thiones through a One-Pot A3-Coupling–Carbon Disulfide Incorporation Process

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Abstract

A copper-catalyzed two-step one-pot procedure for the synthesis of thiazolidine-2-thiones has been developed. The process involves a three-component coupling of an alkyne, an aldehyde, and an amine (A3-coupling) followed by trapping the resulting propargylamine with carbon disulfide and subsequent cyclization.

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Nechaev, A. A., Peshkov, A. A., Van Hecke, K., Peshkov, V. A., & Van der Eycken, E. V. (2017). Synthesis of Thiazolidine-2-thiones through a One-Pot A3-Coupling–Carbon Disulfide Incorporation Process. European Journal of Organic Chemistry, 2017(6), 1063–1069. https://doi.org/10.1002/ejoc.201601103

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