Development of sarcoidosis following completion of treatment for hepatitis c with pegylated interferon- 2a and ribavirin: A case report and literature review

Abstract

Sarcoidosis is a chronic inflammatory multisystem disease of unknown etiology. We report on a woman, aged 57 years, presenting with typical sarcoidosis occurring two months after completion of a six-month course of interferon-α and ribavirin for chronic hepatitis C virus infection. The current observation is interesting with regard to the time elapsed between the occurrence of symptoms and antiviral treatment withdrawal, and spontaneous recovery after ten months of follow-up. Pathophysiological mechanisms involved in the development of antiviral therapyinduced sarcoidosis are discussed. © 2010 Marshfield Clinic.