FORMULATION AND EVALUATION OF CELECOXIB GEL

Abstract

Karade et al Journal of Drug Delivery & Therapeutics; 2012, 2(3): 132-135 Available online at http://jddtonline.info RESEARCH ARTICLE FORMULATION AND EVALUATION OF CELECOXIB GEL *Karade Preeti G1, Shah Rohit R1, Chougule DD1, Bhise SB2 Appasaheb Birnale College of Pharmacy, Sangli, India1 Sinhgad Institute of Pharmaceutical Sciences, Lonavala India2 *Corresponding Author’s E-mail: pritigkarade@gmail.com Received 09 April 2012; Revised 17 April 2012; Accepted 01 May 2012, Available online 15 May 2012 ABSTRACT: The present research has been undertaken with the aim to develop a topical gel formulation of celecoxib, which would attenuate the gastrointestinal relater toxicities associated with oral administration and to investigate the effect of DMSO on permeation of celecoxib. Celecoxib is a highly selective cyclooxygenase-2 (COX-2) inhibitor. In the present study gel with different concentrations of carbapol, sodium alginate and sodium carboxy methylcellulose were prepared. Gels were subjected for various evaluation tests such as pH measurement, spreadibility and extrudability. In-vitro dissolution studies were performed in phosphate buffer of pH 5.6 and polyethylene glycol 400 (7.4 pH) for 12 hrs by using Keshary - Chien diffusion cell apparatus. The gel formulation consisting of 7.5% w/w sodium alginate with DMSO found to be suitable for topical application based on in vitro evaluation. Sodium alginate based gels with DMSO revealed of 90% cumulative drug release after 12 hours. From the above observations, Sodium alginate seems to be a promising pharmaceutical adjuvant in the formulation of celecoxib gels.