An association study of snps with susceptibility to bovine paratuberculosis infection in cattle

Abstract

The study was conducted to identify SNPs of quantitative trait loci (QTL) associated with susceptibility to Mycobacterium avium ssp. paratuberculosis (MAP) infection in cattle. Total 20 SNPs from the cattle QTL database were selected on the basis of the potential role in Mycobacterium susceptibility and a case: control association study was conducted in cattle. Out of 20 SNPs total 17 SNPs were polymorphic and 3 were monomorphic in population. The SNP (rs41945014) was significantly associated with MAP and revealed that ODDs of GG and GT genotypes verses TT genotype were 1.22 (0.33-4.49; 95% CI) and 3.37 (1.23-9.23; 95% CI), respectively. The proportion of GG and GT genotypes were significantly higher in bovine paratuberculosis positive animals suggested that selection against these 2 genotypes may confer resistance against bovine paratuberculosis. The all other 16 polymorphic SNPs of the present investigation were not differing significantly in case-control animals.