Gold-Triggered Uncaging Chemistry in Living Systems

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Abstract

Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cell culture. Furthermore, this solid-supported catalytic system enabled locally controlled release of a fluorescent dye into the brain of a zebrafish for the first time, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.

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Pérez-López, A. M., Rubio-Ruiz, B., Sebastián, V., Hamilton, L., Adam, C., Bray, T. L., … Unciti-Broceta, A. (2017). Gold-Triggered Uncaging Chemistry in Living Systems. Angewandte Chemie - International Edition, 56(41), 12548–12552. https://doi.org/10.1002/anie.201705609

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