TET2 loss, a rescue of JAK2V617F HSCs

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Abstract

In this issue of Blood, Chen et al1 and Kameda et al2 demonstrate that Tet2 loss has 2 effects in Jak2V617F mice: it increases both the severity of the myeloproliferative disorders and the self-renewal properties of the Jak2V617F hematopoietic stem cells (HSCs).

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Vainchenker, W., & Plo, I. (2015, August 8). TET2 loss, a rescue of JAK2V617F HSCs. Blood. American Society of Hematology. https://doi.org/10.1182/blood-2014-10-606624

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