Synthesis of enantioenriched triarylmethanes by stereospecific cross-coupling reactions

Abstract

Coupling with inversion: Chiral diarylmethanol derivatives undergo a stereospecific nickel-catalyzed cross-coupling reaction with aryl Grignard reagents (see scheme). The reaction proceeds with inversion of configuration and high enantiospecificity. The method has been applied to the asymmetric synthesis of a triarylmethane-based anti-cancer compound. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.