Subretinal injection of prourokinase in the treatment of large subretinal hemorrhages

Abstract

8 patients were treated in the Regional State ophthalmologic clinical hospital of Public Health Ministry of Udmurt Republic with subretinal hemorrhage. All performed 25-gage vitrectomy with removal of the posterior hyaloid membrane, subretinal injection of 500 ME prourokinase and air tamponade of the vitreous cavity. In the postoperative period, patients occupied a forced position of the body face up for 2 hours, then were transferred to an upright position for 1 day face down. All patients had resorption of subretinal hemorrhage, visual acuity from 0,009±0,005 improved to 0,15±0,05 (p<0.05; U-criterion). The technique proved to be a highly effective method of rehabilitation of patients with extensive subretinal hemorrhage.