Adult Stem Cell Therapy in Chronic Wound Healing

Abstract

Normal wound healing is a dynamic and complex process involving coordinated interactions between diverse immunological and biological systems. If a wound does not heal in an orderly and timely sequence, or if the healing process does not result in structural integrity, then the wound is considered chronic. It is easy to define a chronic wound, but finding a solution is a complicated matter. Conventional treatment of chronic wounds does not seem to work in several cases, so it is necessary to develop different strategies. Cell therapy constitutes a new alternative to classic methods of wound healing. In this bibliographic review, we present some of the data published up to date on the use of adipose tissue-and bone-marrow-derived Mesenchymal stem cells in patients with chronic wounds caused by several pathologies. Even though cell therapy is a relatively new tool, several studies prove these types of cells may be used safely, and they have demonstrated their efficacy in healing wounds in several cases.