Anticonvulsant activity and toxicity evaluation of CuIIand ZnII metal complexes derived from triazole-quinoline ligands

Abstract

A novel CuII and ZnII complexes of triazolo-quinoline derivatives were synthesized by in situ method and were characterized by the spectro-analytical methods and their pharmacological properties were evaluated. The compound C3 has exhibited promising anticonvulsant activity towards the electroshock induced seizures in Wistar rats and possesses low toxicity, providing a high safety profile. © 2010 Pharmaceutical Society of Japan.