Parkinson’s Disease and Parkin: Insights from Park2 Knockout Mice

Abstract

Parkinson's disease (PD) is a neurodegenerative movement disorder distinguished by resting tremor, bradykinesia, rigidity, postural instability and gait disturbances. Non-motor symptoms including dysfunction of the autonomic nervous system, neuropsychiatric changes, sensory and sleep disturbances are also common. PD may be diagnosed at any age but is most common in aged populations-affecting approximately 1% of individuals over 60 years of age and rising to approximately 4% in age groups above 85 years of age (de …