Sensor based on Copper Nanoparticles Modified Electrochemically Activated Glassy Carbon Electrode for Paracetamol Determination

Abstract

In this paper, copper was electrodeposited by means of cyclic voltammetric technique on the electro-activated glassy-carbon electrode (GCEA). Voltammetric techniques had been utilized for studying the electrochemical behavior of paracetamol (PAC) and its subsequent electroanalysis. CV results show that PAC redox behavior at the copper nanoparticles modified GCE (nano-Cu/GCEA) is largely enhanced. At nano-Cu/GCEA electrode, the redox behavior is diffusion controlled. SWV results show that, the modified electrode (nano-Cu/GCEA) is highly selective and sensitive to PAC quantification. Some likely interferents were addressed and selectivity was improved. The detection and quantification limits were calculated and found to be 0.35 and 1.05 μM, suggesting that the nano-Cu/GCEA can be utilized with high sensitivity and selectivity for the PAC determination. The suggested method successfully utilized for the estimation of PAC in some PAC pharmaceutical samples where it gave recoveries ranging between 97.5 and 108.2%.