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PIK3CA-related overgrowth spectrum: Animal model and drug discovery

Comptes Rendus - Biologies
DOI: 10.5802/CRBIOL.50
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Abstract

This review recapitulates the recent knowledge accumulation on overgrowth syndrome related to gain of function of the phosphoinositide3 kinase (PI3K)-alpha. These disorders, known as PIK3CA related overgrowth syndromes (PROS) are caused by somatic PIK3CA mutation occurring during embryogenesis. We summarize here the currently available animal models and new treatments undergoing development.

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APA

Venot, Q., & Canaud, G. (2021). PIK3CA-related overgrowth spectrum: Animal model and drug discovery. Comptes Rendus - Biologies. Academie des sciences. https://doi.org/10.5802/CRBIOL.50

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