Iridium-catalyzed Mizoroki-Heck-Type reaction of organosilicon reagents

Abstract

Independent of substrate and solvent, the C-C bond-forming reaction of organosilicon reagents with α,β-unsaturated carbonyl compounds can be catalyzed by an iridium complex to give exclusively the Mizoroki-Heck-type addition/elimination product (see scheme). This result sharply contrasts the analogous reaction with a rhodium catalyst under similar conditions in which the 1,4-addition product is obtained preferentially. cod=cycloocta-1,5-diene.