Therapeutic effects of β-thujaplicin eardrops on canine Malassezia-related otitis externa

Abstract

An eardrop solution of β-thujaplicin was examined for therapeutic effects on canine Malassezia-related otitis externa. Half to one ml of β-thujaplicin solution of 100 μg/ml including DMSO 2% was injected everyday into both external ear canals of 31 cases for test-of-cure agreement. Fifteen score phases were established from the symptoms and cerumen smear biopsy findings, and score changes were recorded at least once a week. The means of the second and the third inspection day scores decreased significantly more than the previous value of each. In addition, the numbers of yeast-like organisms clearly decreased. These results suggest that β-thujaplicin eardrops are effective for Malassezia-related otitis externa in dogs.