Abstract
We report the design and synthesis of an aquacarbonyl Ru(ii) dication cis-[Ru(CO)2(H2O)4]2+ reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33. The artificial, non-toxic interleukin (IL)-8-RuII(CO)2 metalloprotein retained IL-8-dependent neutrophil chemotactic activity and was shown to spontaneously release CO in live cells. This journal is
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CITATION STYLE
Albuquerque, I. S., Jeremias, H. F., Chaves-Ferreira, M., Matak-Vinkovic, D., Boutureira, O., Romão, C. C., & Bernardes, G. J. L. (2015). An artificial CO-releasing metalloprotein built by histidine-selective metallation. Chemical Communications, 51(19), 3993–3996. https://doi.org/10.1039/c4cc10204e
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