Effects of feeding on the systemic clearance of indocyanine green and propranolol blood concentrations and plasma binding.

Abstract

In six healthy subjects a 250 g steak significantly increased the systemic clearance of indocyanine green. During a steady‐state infusion of propranolol there was a rapid decrease (mean 35%) in blood propranolol concentrations within 5 min of feeding and levels were reduced for 30 min before gradually returning towards the pre‐feeding. These results suggest that the systemic clearance of high extraction drugs may be increased immediately following food. 1983 The British Pharmacological Society