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LSD1 inhibitors disrupt the GFI1 transcription repressor complex

Molecular and Cellular Oncology (2018) 5(4)
DOI: 10.1080/23723556.2018.1481813
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Abstract

Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.

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Maiques-Diaz, A., Lynch, J. T., Spencer, G. J., & Somervaille, T. C. P. (2018). LSD1 inhibitors disrupt the GFI1 transcription repressor complex. Molecular and Cellular Oncology, 5(4). https://doi.org/10.1080/23723556.2018.1481813

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