Phosphonamidate Prodrugs of a Butyrophilin Ligand Display Plasma Stability and Potent V9 VÎ2 T Cell Stimulation

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Abstract

24 h). These findings increase our understanding of metabolism of butyrophilin ligands and the structure-activity relationships of phosphonamidate prodrugs.

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Lentini, N. A., Foust, B. J., Hsiao, C. H. C., Wiemer, A. J., & Wiemer, D. F. (2018). Phosphonamidate Prodrugs of a Butyrophilin Ligand Display Plasma Stability and Potent V9 VÎ2 T Cell Stimulation. Journal of Medicinal Chemistry, 61(19), 8658–8669. https://doi.org/10.1021/acs.jmedchem.8b00655

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