Investigating the potency of bioactive compounds from ficus religiosa as anti-inflammatory agent

Abstract

The previous studies explain that bioactive compounds from Ficus religiosa are known as an anti-inflammatory agent. In this research, we investigated the potency of bioactive compounds from Ficus religiosa by using molecular docking between eight bioactive compounds and the COX-2 receptor. The eight ligands were collected from www.pubchem.ncbi.nlm.nih.gov., while the receptor was taken from www.rcsb.org. The result of this study could be a reference for the research in the synthesis of the bioactive compound to minimize failure. The collected data was calculated through Autodock Vina embedded in MGL Tools 1.5.6, and these processes were performed using 100 runs of the Lamarckian Genetic Algorithm (LGA). The lowest energy of complexes was visualized by using Biovia Discovery Studio Visualizer. This result proved that 28-Isofucosterol-COX-2 had smaller binding energy compared to the reference ligand.