Amino Acids and Peptides. XIV.1,2) Synthesis and Biological Activity of Three S-Peptide Analogues of Bovine Pancreatic Ribonuclease A (RNase A)

Abstract

Three S-peptide analogues of bovine pancreatic ribonuclease A (RNase A), [Nle1]Lys7] S-peptide (I), [Lys]Nle7] S-peptide (II) and [Nle1]Nle7] S-peptide (III), were synthesized by the fragment condensation method and their ability to reactivate S-protein was examined. It was found that Lys1 and Lys7 both have roles in the reactivation of S-protein. © 1987, The Pharmaceutical Society of Japan. All rights reserved.