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Tethered to survive: Mitotic transcription secures faithful inheritance of extrachromosomal DNA

Molecular Cell
DOI: 10.1016/j.molcel.2025.07.010
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Abstract

In this issue of Molecular Cell, Nichols et al.1 uncover a transcription-dependent tethering mechanism that enables mitotic inheritance of extrachromosomal DNA (ecDNA) in cancer cells, revealing how transcriptionally active ecDNA escapes degradation and drives oncogene persistence through cell division.

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Jin, X., & Verhaak, R. G. W. (2025, August 7). Tethered to survive: Mitotic transcription secures faithful inheritance of extrachromosomal DNA. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2025.07.010

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