My heart will go on-beneficial effects of anti-MiR-30 after myocardial infarction

Abstract

MicroRNAs play key roles in the regulation of diverse cellular processes and during cardiovascular disease development and progression, such as myocardial infarction (MI) and heart failure (HF). A recent manuscript by Shen and colleagues provided evidence that the miR-30-CSE-H2S axis contributes to the protection against cardiomyocyte ischemic injury by regulating hydrogen sulfide (H2S) production. Inhibition of the miR- 30 family after MI injury offers potential therapeutic value to 'keep our heart going on'. As this study highlights miRNAs as promising future therapeutic targets, their translational applicability to utilization in humans needs to be viewed with caution.