Tetramethylfluoroformamidinium hexafluorophosphate (TFFH)/ benzyltriphenylphosphonium dihydrogen trifluoride (PTF): A unique reagent for the conversion of carboxylic acids to the corresponding alcohols as well as hydroxamic acids

Abstract

The present work describes the utility of TFFH (1) for the conversion of carboxylic acids to the corresponding alcohols 4 as well as the hydroxamic acids 5 in the presence or absence of the fluoride additive PTF (3). The addition of the fluoride additive 3 during the activation step improves the yield and purity of the products, due to the fast activation to the acid fluoride derivatives as observed from IR examination. ©ARKAT.