Developmental Onset of bilirubin-induced neurotoxicity involves toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice

Abstract

Background: Neonatal jaundice with dangerously high levels of serum bilirubin leads to neurological toxicity. Results: Toll-like receptor 2 signaling is essential for regulation of glia activation, neuroinflammation, and oxidative stress when neonatal mice experience severe hyperbilirubinemia. Conclusion: Toll-like receptor 2 signaling is linked to a protection mode against serum bilirubin-induced brain toxicity. Significance: Understanding how signaling from innate immunity contributes to bilirubin-induced pathology. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.