Abstract
A double-crossed reaction: The use of proline as an organocatalyst enables a one-pot, direct, cross-Mannich reaction to be performed between two different aldehydes and 4-methoxyaniline in a highly syn-diastereo- and enantioselective manner (see scheme).
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APA
Hayashi, Y., Tsuboi, W., Ashimine, I., Urushima, T., Shoji, M., & Sakai, K. (2003). The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes. Angewandte Chemie - International Edition, 42(31), 3677–3680. https://doi.org/10.1002/anie.200351813
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