The Influence of Corn Silk Polysaccharide on Signal Pathway of TGF-β1 in Type 2 Diabetic Mellitus Rat

Abstract

The study performed some experiments and made following conclusions. In the prevention stage, comparing with normal control group, triglycerides, blood sugar (BG), 24-hour urinary protein and cholesterol (CHO) were higher in T2DM group, but weight and urea nitrogen (BUN) was less in that group. 24-hour urinary protein and cholesterol (CHO) were higher in T2DM group than the intervention group. 24-hour urinary protein and BG in the intervention group were also observed to be higher than the normal control group, but BUN was less than the normal control group. In the intervention group, the weight of kidney and the weight of rat were also higher than T2DM group, but CHO and 24-hour urinary protein were less than T2DM group. The expression of TGF-β1 in T2DM group was also observed to be more than the other groups. However, in the treatment stage, serum creatinine (Cr), weight, BG and CHO, TGand 24-hour urinary protein were significantly higher in the DN rats than those in the normal control rats (P>0.05). The expression level of TGF-β1 and triglyceride level in the corn silk dihydroxycorn silk3 treated group were noticeably lower than those in the DN rats.