The Role of Mitochondrial Genes in Neurodegenerative Disorders

Abstract

Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mi-tochondrial mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of no-ticeable neuropathological lesions in postmortem samples. This review describes various gene mutations in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and stroke. These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mi-tochondrial dysfunctions due to either mtDNA mutation or deletion, the mechanism of which re-mains unclear in depth. © 2022 Bentham Science Publishers.