Selective Para-C−H Alkynylation of Aniline Derivatives by Pd/S,O-Ligand Catalysis

Abstract

Herein, we report a nondirected para-selective C−H alkynylation of aniline derivatives by a Pd/S,O-ligand-based catalyst. The reaction proceeds under mild conditions and is compatible with a variety of substituted anilines. The scalability and further derivatizations of the alkynylated products have been also demonstrated.